Sequential activation of STIM1 links Ca2+with luminal domain unfolding
نویسندگان
چکیده
منابع مشابه
Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1
Oligomerization of the ER Ca(2+) sensor STIM1 is an essential step in store-operated Ca(2+) entry. The lumenal EF-hand and SAM domains of STIM1 are believed to initiate oligomerization after Ca(2+) store depletion, but the contributions of STIM1 cytosolic domains (coiled-coil 1, CC1; coiled-coil 2, CC2; CRAC activation domain, CAD) to this process are not well understood. By applying coimmunopr...
متن کاملChaperone activation by unfolding.
Conditionally disordered proteins can alternate between highly ordered and less ordered configurations under physiological conditions. Whereas protein function is often associated with the ordered conformation, for some of these conditionally unstructured proteins, the opposite applies: Their activation is associated with their unfolding. An example is the small periplasmic chaperone HdeA, whic...
متن کاملModulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57.
STIM1 is an endoplasmic reticulum (ER) membrane Ca(2+) sensor responsible for activation of store-operated Ca(2+) influx. We discovered that STIM1 oligomerization and store-operated Ca(2+) entry (SOC) are modulated by the ER oxidoreductase ERp57. ERp57 interacts with the ER luminal domain of STIM1, with this interaction involving two conserved cysteine residues, C(49) and C(56). SOC is accelera...
متن کاملModulation of STIM1 and capacitative Ca entry by the endoplasmic reticulum luminal oxidoreductase ERp57
Thank you for the submission of your research manuscript to our editorial offices. First of all I would like to apologize for the unusual amount of time it has taken us to get back to you with a decision on your manuscript. Your study has been sent to three referees, and even though we have chased the third referee several times, we have so far only received the reports from two of the experts ...
متن کاملA cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions
STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). The series of molecular rearrangements that STIM1 undergoes until final activation of Orai1 require the direct exposure of the S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science Signaling
سال: 2019
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.aax3194